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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of study design that include the recruitment process and consent, adhering and the use routinely available equipment.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. Too much heterogeneity, however could cause issues with the trial design.

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Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed and regulated by a variety of governing bodies that include the Malta Gaming Authority and UK Gambling Commission. The company's games are protected by high-end encryption, and its security team is available to help players with any issues.

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Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. Despite its relative youth, it has already established itself as a top gaming platform for casinos. The latest releases include Wolves 5 reel video slot with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to assess the causality of an intervention with its outcomes. They should, however, not be used to replace explanation studies.

The idea of pragmatism is controversial, 프라그마틱 정품 확인법 and there are questions about whether pragmatic trials should replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the features of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary-care settings.